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Manually curated information which has been propagated from a related experimentally characterized protein.

If too much of one of these molecules is made, glutamine synthetase senses this and slows production slightly. Glutamine is produced industrially using mutants of Brevibacterium flavum, which gives ca. doi:10.1016/0020-711X(84)90061-2. It is one of the conditional-essential amino acids in a few situations such as gastrointestinal disorders or intensive athletic training. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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The nature of the metal is indicated in the 'Description' field.

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Manual assertion inferred from sequence similarity toManual assertion inferred from sequence similarity to

Oligodendrocytes support neuronal glutamatergic transmission via expression of glutamine synthetase.

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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It always involves more than one amino acid and includes all residues involved in nucleotide-binding.

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Manual assertion inferred from sequence similarity toManual assertion inferred from sequence similarity to

This section is used to point to information related to entries and found in data collections other than UniProtKB.

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It is useful for tracking sequence updates.



The algorithm is described in the ISO 3309 standard. 16 (1): 117–20.

Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.

Nucleotide biosynthesis is critical for cellular function.

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Glutamine synthetase.

The information is filed in different subsections. Some of the functions and glutamine uses are as follows. Asparagine synthetase catalyzes the production of asparagine and glutamate from aspartate and glutamine in an ATP-dependent amidotransferase reaction [18,59].

This subsection of the 'Entry information' section provides one or more accession number(s).

This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier.

This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.

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Manual assertion inferred from sequence similarity to Function. Competition between Glutamine synthetase can be composed of 8, 10, or 12 identical subunits separated into two face-to-face rings.GS catalyzes the ATP-dependent condensation of glutamate with ammonia to yield glutamine.ATP binds first to the top of the active site near a cation binding site, while glutamate binds near the second cation binding site at the bottom of the active site.GS is present predominantly in the brain, kidneys, and liver.Plants have two or more isozymes of GSII, one of the isozymes is translocated into the While the three classes of GSs are clearly structurally related, the sequence similarities are not so extensive. This is mostly done in the muscles and sometimes in the lungs, brain tissues and the liver.The human body synthesizes more amount of glutamine which is further involved in numerous biochemical process of life.

This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.

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Competition between Glutamine synthetase can be composed of 8, 10, or 12 identical subunits separated into two face-to-face rings.GS catalyzes the ATP-dependent condensation of glutamate with ammonia to yield glutamine.ATP binds first to the top of the active site near a cation binding site, while glutamate binds near the second cation binding site at the bottom of the active site.GS is present predominantly in the brain, kidneys, and liver.Plants have two or more isozymes of GSII, one of the isozymes is translocated into the While the three classes of GSs are clearly structurally related, the sequence similarities are not so extensive.Inhibition of GS has largely focused on amino site ligands.Feedback regulation distinguishes the difference between two eukaryotic types of GS: brain and non-brain tissues.

This section provides information on the location and the topology of the mature protein in the cell.

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Manual assertion inferred from sequence similarity to

Organism. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993))

Abstract As a highly regulated enzyme at the core of nitrogen metabolism, glutamine synthetase has been studied intensively.

An evidence describes the source of an annotation, e.g. Astrocytes protect neurons against excitotoxicity by taking up excess ammonia and glutamate.

This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.

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This amino acid has one carboxyl group, one amino group along with the amide group in the side-chain of the The essential amino acids are the ones which are very much necessary in our diets as the body does not synthesize it or builds them for any other chemicals.

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