Yes, I have been prescribed promethazine while on Sudafed PE, and the doctor was aware. Serious, life-threatening side effects can occur if you take Promethazine with DM before the MAO inhibitor has cleared from your body.
We will be writing to the marketing authorisation holder to request changes to the packaging to address this.”MERLE BEAL, consumer and medical affairs director, GlaxoSmithKline Consumer Healthcare, responds: The current Night Nurse Liquid carton does, indeed, state “Promethazine, with decongestant action to dry up runny noses and sniffles, so easing breathing”.
Promethazine is an H1 receptor-blocking agent (antihistamine). I am not persuaded by anything I have read either in the SPC or in other reference sources that this active could be described as a decongestant. They also have mild central stimulant action, which renders them marketable as non-sedating.Promethazine has none of those effects. 2015-02-12 16:43:50 2015-02-12 16:43:50. pseudoephedrine oral brand names and other generic formulations include:. Promethazine has none of those effects.
This report displays the potential drug interactions for the following 2 drugs:Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some mixtures of medications can lead to serious and even fatal consequences.Viltepso (viltolarsen) is an antisense oliogonucleotide indicated for the...Evrysdi (risdiplam) is a survival of motor neuron 2 (SMN2) splicing...Olinvyk (oliceridine) is an opioid agonist for the management of moderate to...Lampit (nifurtimox) is a nitrofuran antiprotozoal used for the treatment of...The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. What caught my attention is the claim that promethazine has a decongestant action. I telephoned GSK’s medicines information department for clarification but it offered no explanation. It is in fact a sedating antihistamine which has secondary antimuscarinic effects which may result in a drying of mucous membranes but this is not the main action of this active moiety. New artwork for the carton that includes this clarification has been commissioned and submitted to the MHRA for review. No interactions were found between promethazine and Sudafed 12 Hour Pressure+Pain. In community pharmacy, that distinction is important. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information -
For example, pharmacy assistants are taught that patients who suffer from hypertension should avoid decongestants because they can increase blood pressure. The statement regarding promethazine being a decongestant has been on the labelling for many years but I agree that this is not appropriate. Subscribe to our free alerts. promethazine; Sudafed 12 Hour Pressure+Pain (naproxen/pseudoephedrine) Edit list (add/remove drugs) Interactions between your drugs. For commenting, please login or register as a user and agree to our Pharmaceutical Press is the publishing division of the Royal Pharmaceutical Society, and is a leading provider of authoritative pharmaceutical information used throughout the world.Want to keep up with the latest news, comment and CPD articles in pharmacy and science? This wording has been included on the carton for over 20 years and was approved by the MHRA. It said it would reply to me via email but I am still waiting. This does not necessarily mean no interactions exist. Promethazine is an H1 receptor-blocking agent (antihistamine). Once approved, the new carton for Night Nurse Liquid will be introduced. Surprisingly, the decongestant claim is not made for Night Nurse Capsules despite identical ingredient composition.Can GSK be deliberately redefining decongestion specifically for Night Nurse Liquid in order to qualify its label claim for promethazine? In consultation with the MHRA at the end of 2011, GlaxoSmithKline undertook to revise the wording to be more consistent with the information given in the product leaflet, which states that promethazine hydrochloride is an antihistamine that dries up a runny nose and aids restful sleep. Wiki User.
Further queries on this matter can be directed to the medical information direct line (tel +44 (0)20 8047 250). It is my view that mention of a decongestant on this product is misleading since as you point out hypertensive patients will know not to self-medicate with products which claim a decongestant action. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects.In community pharmacy, that distinction is important. They mainly relieve nasal congestion by vasoconstriction of the blood vessels in the nasal mucosa. I have contacted the head of patient information quality at the Medicines and Healthcare products Regulatory Agency, who wrote back to me in these terms: “I have noted your comments and am in agreement with the points you have raised.
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